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PPP did not compete with ATP but interfered with phosphorylation in the activation loop of the kinase domain, in which it specifically blocked phosphorylation of the tyrosine (Y) 1136 residue, while sparing the two others (Y1131 and Y1135)

Moreover, targeting the later phases of DTPs in which they evolve to genetically resistant cells is of potential importance

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Production can be impaired by insufficient nutrient cofactors and genetic variations in the enzymes involved in the synthesis and regeneration of glutathione