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Consequently, inhibiting ACSL4 expression represents an important direction in ferroptosis research (43)

Liver-specific knockdown of long-chain acyl-CoA synthetase 4 reveals its key role in VLDL-TG metabolism and phospholipid synthesis in mice fed a high-fat diet

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Gulati, S., McQuillen, D

In the landmark 2017 study, FOXO4-DRI selectively induced apoptosis in senescent human fibroblasts (IMR90 cell line) while sparing non-senescent cells at an 11.73-fold selectivity ratio