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One major issue is difficulty in attributing mechanisms: It remains unclear whether their neuroprotective effects arise specifically from ferroptosis inhibition or indirectly through anti-inflammatory, anti-aggregation, or mitochondrial protective pathways, and genetic evidence is lacking (e.g., validation in GPX4 conditional knockout models)

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Toxicity reduction and efficacy promotion of doxorubicin in the treatment of breast tumors assisted by enhanced oral absorption of curcumin-loaded lipidpolyester mixed nanoparticles