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However, these proportions shifted towards the control distribution following L-serine administration (Supplementary Fig

1996 Jun;2(3):161-71

The datasets generated and analysed during the current study are available in the Gene Expression Omnibus (GEO) server with access number GSE232691

* These statements have not been evaluated by the Food and Drug Administration

At the extreme end of this situation, where there is a genetic deficit in carnitine biosynthesis, some nasty stuff happens without carnitine supplementation [1]: Liver damage and dysfunction Brain damage Muscle weakness Lethargy Exercise intolerance Yet, there can also be situations of mild deficiency where these overt signs arent present

On the other hand, if reduced expression of a polynucleotide or polypeptide is desired, then the nucleic acid may be, e.g., an antisense oligonucleotide, siRNA, or microRNA that comprises a polynucleotide sequence that specifically hybridizes to a polynucleotide that encodes the target polypeptide, thereby disrupting expression of the target polynucleotide or polypeptide