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This review is not intended to provide a detailed analysis of the effect of Nrf2 activation or inhibition on aging processes, which has been done previously [2]

Other nonenzymatic antioxidant systems, such as vitamins C and E, may also display selective, context-dependent effects rather than exerting global protein reduction, suggesting that a deeper understanding of antioxidant specificity is critical for developing targeted therapies (61, 62)

Maarif, B

1 2 "Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzyme"

Glutathione exists primarily in two interrelated forms: Reduced glutathione, or GSH: the form able to donate electrons within antioxidant and redox reactions Oxidized glutathione, or GSSG: the form produced after two glutathione molecules form a disulfide bond The body continually recycles oxidized glutathione back into reduced glutathione through enzyme systems that depend partly on cellular energy and nutrient availability

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