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The mRNA levels of -catenin downstream genes, including Lef1, Cyclin D1, and Myc, were increased, as determined by RT-qPCR

Adapted from Fraser et al

The UK guidelines do allow for this

8 , e2731 (2017)

One practical consequence of the triple mechanism: because three pathways are being engaged simultaneously, the total physiological load at any given milligram is higher than a single- or dual-agonist at the same number