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Glutamine is a non-essential amino acid with a high content in the normal human body that can provide a nitrogen source for the synthesis of purine and pyrimidine nucleotides, participate in the TCA cycle, and contribute to its carbon backbone, particularly when carbon is diverted to glycolytic pathways

Sun Y, Zhao Y, Yao J, Zhao L, Wu Z, Wang Y

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Men are 1.2 times more likely to develop ESRD compared to women

Another important group of modifications is protein tags, which provide intracellular localization of proteins such as marking the proteins for transport to the proteasome, where they will be proteolyzed and hydrolyzed

doi: 10.1038/s41392-025-02486-3 72 FontanaLEagonJCTrujilloMESchererPEKleinS