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A seminal study by Alfaifi et al

By reducing heart rate, contractility, and arterial pressure, beta-blockers reduce the work of the heart and the oxygen demand of the heart

Voet D, Voet JG

For example, the content of drugs can be detected in tears and aqueous humor through ELISA (Enzyme-linked Immunosorbent Assay) or HPLC (High Performance Liquid Chromatography) in vitro [329, 330]