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Some genes, like vascular endothelial growth factor C (VEGFC) and the tyrosine kinase receptor VEGF receptor 2 (VEGFR2), are turned down by EGCG (132)

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But later trials never lived up to the promise, or further trials were not pursued because pharmaceutical development of the drug was terminated

The First Occurrence of Angioedema After Discontinuation of Angiotensin-Converting Enzyme Inhibitor