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For global splicing analyses, we only considered the 6222 major isoforms of protein-coding genes with a prevalence higher than 70%, no overlap with other genes, and with read counts per kilobase (RPK) higher than 50, as previously described 8,73

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Pairwise end-to-end distances are computed between the mass centers of the non-hydrogen atoms comprising on each side the three linker DNA base pairs 88th through 90th

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Int J Radiat Oncol Biol Phys 72(1):210-19, 2008

Ionizable Lipids In order to overcome the limitation of cationic lipids and further improve the RNA delivery efficiency, numerous ionizable lipids with ionizable amino head groups have been developed as a critical component for the formulation of LNPs