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The inflammatory process was attenuated by berry extracts by decreasing inflammatory cell infiltration 9,36,39,41,49 and gene and protein expression of inflammatory markers such as TNFa, 9,34,36,41 43,45,50,52 Il1b, 9,34,36,42,43,50,52 Il6, 34,38,41,42,50 Il10, 45 Nfkb, 4,23,34,41,43,45 Ppara, 38,43 Ptgs2 (COX-2), 34,41,43 Ccl2, 18,43 Ccl3, 43 Ccr2, 43 Tgfb, 42,45 Nlrp3, 43,45 Nlrp6, 45 Casp1, 43,45 Nr1h3 (Lxra), 32,40,44 Icam1, 42 Itgax (CD11c), 42 Fabp4, 5,32,34 F4/80, 42 Pycard (ASC), 45 and Tlr4

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Additionally, the expression levels of the pro-inflammatory cytokines IL-6, IL-1, IL-17A, and IL-23A were significantly increased in the IMQ-treated group compared to the control group, but were significantly reduced by rutin