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The interaction is not always a contraindication but it changes the protocol

When starting patients on therapy, it is important that baseline and ongoing renal and liver function tests are taken because renal disease or liver disease may be a primary complication of IBD itself[1]

It acts prominently on nitric oxide (NO) signaling , counteracting the damaging effects of NO inhibition (e.g., L-NAME) and modulating eNOS through the upregulation of antioxidant enzymes (e.g., HO-1)

GHK-Cu A tripeptide (Gly-His-Lys) that forms a coordination complex with copper(II), giving the characteristic blue-purple color