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Box A: Diversity of GPCR ligands Neurotransmitters norepinephrine adenosine histamine serotonin dopamine cannabinoids opiates acetylcholine GABA glutamate Peptide hormones endothelin glucagon angiotensin II GSH, FSH, CRH GnRH, ACTH Tastants, oderants, light Learning Objectives 1

Loss of growth hormonemediated signal transducer and activator of transcription 5 (STAT5) signaling in mice results in insulin sensitivity with obesity

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The notes below describe what to watch for when running all three together