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In vivo studies showed that specific deletion of myeloid cell Gpx4 in mice exhibited SLE-like clinical manifestations, which could be alleviated by treatment with liproxstatin-1, an ferroptosis inhibitor, and attenuated disease progression

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The gene expression PCA plot confirmed transcriptomic-wide differences between GSH-sufficient Gclc fl/fl MZB and Gclc fl/fl FoB (Fig

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The Neh6 domain, which is a serine-rich region, contributes to regulate NRF2 stability and mediates the interaction with a third negative regulator, -transducin repeat-containing protein (-TrCP), through its DSGIS (Aspartic acid-Serine-Glycine-Isoleucine-Serine) and DSAPGS (Aspartic acid-Serine-Alanine-Proline-Glycine-Serine) motifs not recognized by KEAP1