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Additionally, ligand-trap agents such as luspatercept (TGF-/activin inhibition, facilitating late-stage erythroid differentiation) (Santini and Consagra, 2025), BRAF inhibitors that treat anemia through activation of MAPK signaling (Wu et al., 2024), and low-cost host-defense peptides with anti-inflammatory properties (e.g., IDR-1018) ( Figure 1 Statements Author contributions F-FL: Investigation, Writing original draft

Kate Harris is the founder and owner of The Kate Harris Group , where she helps organizations navigate change with integrity and curiosity, bringing a thoughtful and strategic approach to leadership

Nash, PhD, Centers for Behavioral and Preventive Medicine, Brown Medical School/Miriam Hospital, Coro 500, One Hopping Street, Providence, RI, 02903

3, 29, 30 Oxidative Damage and Oxidative Modification of Proteins in Autoimmune Disease Autoimmunity results from the abrogation of self-tolerance and is involved in several human diseases

Orbitofrontal cortex function and structure in depression

(b) The role of metabolic reprogramming in ferroptosis, analyzing how lipid, amino acid, iron, and glucose metabolism are reshaped or disrupted in OA, thereby influencing the occurrence and progression of ferroptosis