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Hindmarsh PC, Matthews DR, Brain CE, Pringle PJ, di Silvio L, Kurtz AB, et al

(2025) 9:bvaf061

A recent metallomic study has found significantly lower cortical lithium (Li) in mild cognitive impairment and AD with selective sequestration of Li within amyloid plaques, implying an early disturbance of endogenous Li homeostasis in vulnerable cortex while serum levels remain unchanged