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doi: 10.1017/s1092852924000518 34 KhavariBMahmoudiEGeaghanMPCairnsMJ

This antioxidant action helps protect against oxidative stress, which is implicated in various health issues and accelerated aging

Bloino, J

We, therefore, sorted the metabolic reactions identified by the Compass algorithm into two groups: glycolysis and TCA

In addition, hemodynamic alterations, such as increased cardiac pre- and afterload, contribute to mechano-energetic uncoupling in HF, especially with preserved ejection fraction (HFpEF), which results in mitochondrial oxidative stress as an important upstream mediator of cardiac remodeling and dysfunction [2]