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The Center for Biologics Evaluation and Research (CBER) published three updated standard operating policy and procedures (SOPP) used by agency staff when reviewing products, including one on expediting the review of breakthrough therapies

Blimp-1 Orchestrates Plasma Cell Differentiation by Extinguishing the Mature B Cell Gene Expression Program

However, adverse effects such as gastrointestinal discomfort, headache, dizziness, and allergic skin reactions have been reported in humans

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However, wogonin displays very low oral bioavailability (1.10%), likely resulting from poor solubility and extensive first-pass metabolism (Hassanin et al