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The time of Maria Panagioti and Natasha Tyler was funded by the National Institute for Health and Care Research (NIHR) Greater Manchester Patient Safety Translational Research Centre (award number: PSTRC-2016-003)

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Solid neoplasms Myeloproliferative blood disorders Liver diseases Dementia Depression ADHD Schizophrenia Psychosis Refractory treatment of vitamin B12 deficiency, particularly with hydroxocobalamin and cyanocobalamin Chronic Viral Diseases Lyme disease Prolonged antibiotic treatment Parkinson's Disease Peripheral Neuropathy Paresthesia Pain and numbness in fingers or toes Fatigue Insomnia Dizziness Pain in joints Stomach complaints Difficulty focusing Mood changes Elevated homocysteine Elevated MMA Prolonged oral treatment with vitamin B12 in which serum B12 levels rise but there is no change in symptoms Elevated urinary oxalates or urolithiasis Pyroluria Lung cancer Short Bowel Syndrome All cause Mortality and Paradoxical B12 Deficiency Elevated B12 levels have been associated with higher mortality rates in the elderly (Salles etal, 2008

A deficiency in B12 can lead to symptoms such as fatigue, weakness, memory problems, and neurological issues

For example, those who are following a healthy diet and are exercising, are likely going to see better weight loss results than those who are not doing the same

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