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& Orkisz, S

Magnolol demonstrated dose-dependent enhancement of phagocytosis and inhibition of NO production at the concentration range of 10-40 M, whereas, in a DSS-induced colitis model, magnolol improved colitis symptoms, including body weight loss and colon length, attenuating pro-inflammatory cytokine levels and histopathological manifestations via modulation of MAPK and NF-B signaling pathways [485]

Sprayed directly on clean skin twice daily, the subnano format also circumvents the digestive system

J Nutr 139:23932396

So thats a really long, randomized controlled trial and strengthens the quality of the evidence