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10.1126/sciadv.abb3063 224 XueQ.YanD.ChenX.LiX.KangR.KlionskyD

Vitamin B12: High levels of stress and poor gut health can lead to B12 depletion, which is often linked to early hair color loss

PCOS is characterized by insulin resistance in many (though not all) patients the body's cells don't respond normally to insulin, leading to compensatory hyperinsulinemia (high circulating insulin), which in turn drives excess ovarian androgen production (testosterone and DHEA), disrupts follicular development, and impairs ovulation

doi: 10.3389/fmicb.2022.918823 83 Regueira-IglesiasA.Balsa-CastroC.Blanco-PintosT.TomasI

doi: 10.1016/j.jafr.2023.100559 210

Their study found that, even after adjusting for body mass index (BMI), T2DM remains a causally related risk factor for IDD