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Accumulating evidence has revealed that curcumin also prevents tumorigenicity and self-renewal attributes of glioma-initiating cells by inducing autophagy, which prevents the development and recurrence of glioblastoma [119]

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doi: 10.1016/j.canlet.2020.02.002 23 ZhaoJChenAXGartrellRDSilvermanAMAparicioLChuTet al

Given the substantial induction of HIF-1 mRNA and protein in response to T cell activation and the well-known role of HIF in driving glycolytic metabolism, several groups have recently explored potential HIF function in adaptive immune responses