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Emerging strategies, including nanotechnology-based delivery systems and combination therapies, aim to overcome these barriers, enhancing the efficacy and applicability of antioxidants in combating neurodegenerative diseases

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During both the OE-1 and OE-2 tests, approximately 4% and 1% of activated cells were defined as positively or negatively correlated neurons, regardless of genotype (Fig 5C), indicating that Tbr1 +/ mice do not differ from WT mice in terms of numbers of activated neurons during OE

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This process occurs through mitochondrial fusion facilitated by intercellular tunneling nanotubes, which are crucial for counteracting the detrimental effects of ferroptosis on neurons

These cells are classically divided between those considered protoplasmatic and those considered fibrous, by their grey and white matter origins, respectively