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The management of GBM is hampered by several challenges, including tumour heterogeneity, the presence of therapy-resistant glioma stem cells, the highly infiltrative growth pattern of tumour, primary and acquired drug resistance, and BBB, which restricts drug delivery 7,8,27,28,29

26,27 Moreover, the iron exporter ferroportin (FPN) has also been shown to regulate cellular sensitivity to ferroptosis in vitro

however, recent findings indicate that amyloid formation in vivo may be promoted by disulfide bond formation between TTR subunits, suggesting oxidative stress as a potential contributor to protein misfolding and disease progression

It is well-known that the gut microbiota activates the growth and development of the immune response and plays a vital role in immune cell maturation, too

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doi: 10.1093/brain/awac389 119 O'CarrollSJKhoDTWiltshireRNelsonVRotimiOJohnsonRet al