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doi: 10.1093/jn/134.3.489 [DOI] [PubMed] [Google Scholar] 12.Whiting PH, Kalansooriya A, Holbrook I, Haddad F, Jennings PE

The reaction is catalyzed by GST

In the resting state, NMDAR channels are normally blocked by Mg 2+ , but when large amounts of glutamate accumulate, activated AMPAR causes partial depolarization of the postsynaptic membrane, sufficient to clear the Mg 2+ on the NMDAR

For example, DNA strand breaks and reversible cross-links with DNA or histone proteins of nucleosome core particles from AP sites affect transcription and replication in cells, further inducing gene mutations, which may cause apoptosis or cell carcinogenesis [19, 20]