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The reported brain concentrations of kynurenines are even lower with 0.41.6 nmol/g for QUIN (Wolfensberger et al., 1983), 0.010.07 nmol/ml for KYNA (Moroni et al., 1988), and 0.016 nmol/g for 3HANA (Baran and Schwarcz, 1978)

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This is the primary reason why we emphasize the importance of formulation quality over raw dosage

As mentioned before, after leakage, RBCs undergo lysis with the subsequent release of Hb molecules, which are engulfed by the neuronal cells via binding to the neuronal receptor CD163