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Dehydroascorbate reductase consumes reduced glutathione to produce ascorbate, which is then used for the detoxification of hydrogen peroxide

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(2018) 13:e0196716

Journal of Applied Physiology

In intestinal epithelial cells, this enhanced contractile tension induces centripetal contraction of the perijunctional actomyosin ring, leading to internalization and reorganization of junctional proteins, including claudins, occludin, ZO-1, and adherens junction components, resulting in reversible TJ opening and increased paracellular permeability

phosphorylated GSK3 (Ser9) level was significantly downregulated in Prx II-knockdown HaCaT cells after H 2 O 2 treatment, accompanied by a marked decrease in the phosphorylation levels of its upstream kinase PI3K and AKT (Fig