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Research indicates that vodobatinib and IKT-148009, two next-generation c-Abl inhibitors, exhibit superior brain penetration and more potent inhibition of cerebral c-Abl compared to nilotinib, showing considerable promise for PD treatment [160162]

28 It has been reported that transformation of SAM to SAH determined the transsulfuration pathway activity, inducible of which contributed to cellular cysteine pool and promoted cancer cell growth upon cysteine restriction

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Eight female pups received normal saline (10 mg/kg) as a control group

Although the efficacy of tretinoin in melasma management has been established, however, a minimum treatment duration of 24 weeks is required to achieve the clinical effectiveness