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Taking too much glutamate can cause seizures and kill brain cells

C.LiQ.WangR.ZhangC.et al (2014)

Ipsen DH, Tveden-Nyborg P, Rolin B, Rakipovski G, Beck M, Mortensen LW, Faerk L, Heegaard PM, Moller P, Lykkesfeldt J (2016) High-fat but not sucrose intake is essential for induction of dyslipidemia and non-alcoholic steatohepatitis in guinea pigs

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[People] may not even know theyre B12 deficient until they start manifesting some more severe symptoms, which may initially present as just agitation and anxiety, before progressing into more serious psychiatric disorders, says Bottiglieri