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In a phase 2 trial, setmelanotide was dosed at 1 mg/24 h SC infusion over 90 days (NCT01749137) (87)

Five studies with 147 participants showed a reduction in the incidence of muscle cramps with L-carnitine group (pooled OR = 0.22, 95% CI [0.060.81], p = 0.02, I 2 = 74.7%)

Exclusion of competing etiology: A careful history and work up for exclusion of competing etiology is crucial as DILI is primarily a diagnosis of exclusion

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Malaguarnera and colleagues randomized 74 patients with NASH to receive either L-Carnitine (a 1 gram tablet after breakfast and another after dinner) or placebo for 24 weeks

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