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Small molecules such as Idebenone often exhibit poor bioavailability, variable mitochondrial uptake across tissues, and limited penetration of critical barriers, notably the blood-retinal and bloodbrain barriers [238]

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Flavonol content was determined using quercetin as a standard, according to Mazza et al

A previous study revealed that dietary supplementation of BCAAs in middle-aged mice is associated with increased mitochondrial formation and bioenergetics as well as reduced ROS production, which could prevent aging and promote survival (Takegoshi et al., 2017)

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