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MET in the diets did not affect GST activity in dwarf mice, whereas wild-type mice lost activity with increasing concentrations of MET

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however, the difference between the two groups was not significant

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Metabolic re-wiring that limits the malate-aspartate shuttle and mitochondrial substrate oxidation, and promotes aerobic glycolysis, the re-oxidation of NADH by MDH1, folate cycle NADPH production, and pentose phosphate supply by the non-oxidative PPP may thus constitute a successful strategy for minimizing ROS production and supporting high proliferation rates in oxygen-rich environments