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115 In individuals assigned to a VLCKD, the body weight (weighted mean difference [WMD]0.91 kg, 1,415 patients), TG (WMD 0.18 mmol/l, 1,258 patients), and diastolic blood pressure (WMD-1.43 mmHg, 1,298 patients) decreased, whereas HDL-C (WMD 0.09 mmol/l, 1,257 patients) and LDL-C (WMD 0.12 mmol/l, 1,255 patients) increased, and resulted in a greater weight loss than in those assigned to a low-fat diet in the long term

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Interestingly, gemcitabine has already been proposed as an adjuvant in combination with another MEKi, trametinib, in adenocarcinoma treatment, but due to low efficacy, the studies were terminated [70]

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