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Obesity can worsen low-grade inflammation, which can, in turn, lead to neuroendocrine dysfunction

As further consideration of translation of this therapeutic to the clinic, cochlear synaptopathy is implicated as a potential contributor to human tinnitus, although the published evidence is emerging and, so far, is largely indirect 11,60

gRNAs sequences are shown in Supplementary Table S1 and list of plasmids in Supplementary Table S2

It is contraindicated for individuals with hypercalcemia, hypercalciuria, or severe renal impairment

NPJ Biofilms Microbiomes 8 , 86 (2022)

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