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2014 Feb 20;370(8):773-6

Measuring mucosal healing, cytokine levels, and tissue histology in combination protocols would clarify potential interactions

Impact of Clostridium difficile on inflammatory bowel disease

The textbooks describe a stepwise approach from mesalamine or sulfasalazine, through systemic prednisone with or without an immunomodulator (such as azathioprine, methotrexate or 6-mercaptopurine), to TNF-alpha inhibitor biologics, injectable medicines that block a key inflammation signal (infliximab, adalimumab, golimumab or certolizumab pegol), the IL-12/IL-23 inhibitor ustekinumab, or the anti-adhesion antibody vedolizumab for refractory disease

doi: 10.1038/ejcn.2014.46

Andrew Huberman notes that despite its popularity and extensive animal studies, there is only one poorly conducted human study, leaving much about its behavior in the human body, including its pharmacokinetics, still unknown 2