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The primary and most important mechanism of how Botox works for chronic migraine is by disrupting the electrical communication signals of pain between nerves involved in migraine pathophysiology and ultimately stopping these signals from reaching the pain circuitry of the brain

To eliminate a violation of the 2 times rule and improve clinical and resource homogeneity in the APCs for which we did not propose a 2 times rule exception, we proposed to reassign these procedure codes to new APCs that contain services that are similar with regard to both their clinical and resource characteristics