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In peripheral tissues, BHB is oxidized into AcAc in the reverse reaction catalyzed by BDH1 (Newman and Verdin, 2017

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Pro-oxidant iron is present in human pulmonary epithelial lining fluid: implications for oxidative stress in the lung

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SOURCE Acetaminophen (also known as Paracetamol) depletes glutathione

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These changes can cause a cascade of oxidative damage that can systemically make its way to the male reproductive system, thereby affecting fertility

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J Biol Chem 289:16621674

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