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Savvides P, Nagaiah G, Lavertu P, Fu P, Wright JJ, Chapman R, et al

World J Gastrointest Pharmacol Ther 2020

AMP Kinase (AMPK): AMPK, a key energy-sensing kinase, modulates the activity of glutamine-PRPP amidotransferase to ensure that nucleotide synthesis is in sync with cellular energy status

Published data suggests up to 2.6% incidence of B12 deficiency within a year of treatment, and this figure climbs in patients who have used these medications long term or combined them with very low calorie diets (3)