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More injections and/or higher doses will be needed for better results

J Biosci

The quantitative data mentioned above on a depletion of the total specific content of ATP in cultured astrocytes by application of inhibitor of ATP regenerating pathways have been confirmed by ATP sensor studies showing a corresponding decline in the cytosolic ATP content of astrocytes in different model systems (Table 4)

To assess for possible kidney damage, we quantified cystatin-C instead of the typical markers such as blood urea nitrogen and creatinine ratio, as it is a better marker of renal homeostasis [46]

Lipid metabolism can modulate apoptosis and autophagy by affecting the production of ROS, activation of signaling pathways, and formation of lipid droplets or membrane structures (192)

These data suggest that alternative oxidase can be crucial under nitrosative stress: The high alternative oxidase activity can maintain respiration at low cytochrome c oxidase activity and reduces the activity and hence superoxide production of cytochrome bc1 complex