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MITF regulates IDH1, NNT, and a transcriptional program protecting melanoma from reactive oxygen species

Lin LF, Li H, Lin HM, Zhang M, Qu CH, Yan L, et al

Recent evidence shows that metastatic tumors are more transcriptomically like their target tissues, suggesting their ability to mimic organ-specific microenvironmental components to gain support at metastatic sites [60]

These safety assessments must unequivocally demonstrate that genetically modified organisms cannot persist in the environment, lack transferable antibiotic resistance markers, and are incapable of disseminating any deleterious genetic material to other microbiota (99)

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