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Assuming benthic foraminiferal diversity and test isotopic variability are reliable indicators of hydrographic conditions at the sediment-water interface, a reconstruction of SGD indicates local water balance changes during the last 2000 years

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These may include increased thirst and urination, increased appetite, and potential risks to liver function

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- Amphotericin B: by the increase in potassium depletion - Diuretics that produce potassium depletion (thiazides, furosemide) by increasing the potassium depletion and the risk of severe hypokalemia

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