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Arg33, Ser44, Gly45, Glu50, Arg62, Glu65, Cys66, Glu87, Glu88, Glu91, Ala94, Gly95, Tyr96, Asn97, Pro167, His168, and Phe170 enhanced water bridge with Liproxstatin-1

Among these two kinases, mTORC1 plays a key role in maintaining metabolic homeostasis, protein and lipid synthesis, glycolysis, mitochondrial biosynthesis, and lysosomal function by sensing various stimuli, such as amino acids, growth factors, and oxygen, thereby regulating activity of transcription factor and directly modulating translation processes

Upon reaction with GSH in cancer cells, dissociation of MOFs will occur, and the released drugs exert chemotherapy efficacy (Wang et al

By the end of the treatment study, these biomarkers had all improved or even normalized

Dense binding is observed in the caudate, putamen, cerebral cortex, and amygdala, while they are generally sparse to inexistent in thalamus and hypothalamus

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