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Physiological effects, such as temporary fatigue, drowsiness dizziness, or fluctuations in blood pressure and heart rate have also been observed in limited cases

Donidalorsen is labeled for self-administration of an 80-mg dose via subcutaneous autoinjector once every 4 or 8 weeks -- less frequent dosing compared with other options for prophylaxis

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Because this combination is not approved yet, healthcare providers will eventually closely monitor patients for gastrointestinal side effects, such as nausea, vomiting, or constipation, and adjust doses accordingly to maximize benefits while minimizing discomfort