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Since it was determined that NO has a vital role in the control of blood flow, scientists have speculated on the effects increased levels would have on cardiovascular functioning in particular and exercise performances in general

reference number 20-1122)

We thank Qin Deng and Guocan Zheng in Analytic and Testing Center of Chongqing University for use of the facility and technical support for confocal and GCMS/MS analysis, ShanghaiTech School of Life Science and Technology Core facility, and Ying Han for their assistance with sphingolipid profiling and quantification, and Yu Kong and Lijun Pan (Electron Microscopy Facilities of Center for Excellence in Brain Science and Technology, CAS) for assistance with EM sample preparation and EM image analysis

Supplementary material The Supplementary Material for this article can be found online at: Abbreviations TMAU, trimethylaminuria

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