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The final assessment of these serious adverse events described them as akathisia secondary to venlafaxine treatment and not serotonin syndrome.55 The second case was a patient who was hospitalized for drug overdose while receiving STS in an open-label extension study following double-blind therapy.55 The patient had been taking several contraindicated medications, including nortriptyline, bupropion, and a sympathomimetic agent for weight loss, and was wearing 2 STS patches simultaneously (12 mg/24 hours each)