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Two antisense oligonucleotides that specifically interact with the mRNAs of the protein kinase C-, responsible for tyrosinase phosphorylation and thus its activation [115], decreased tyrosinase activity in cultured melanocytes and reduced hand pigmentation in volunteers after applying a care product containing these synthetic agents [116]

Similarly, data in advanced liver disease are sparse

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In contrast to an earlier study that also found such matched contralateral lesions (Werring et al., 2000), this more recent report detected such mirror precursory lesions well before a T2 lesion formed in the index hemisphere, precluding the previous explanation of axonal transection and Wallerian degeneration as a possible contributor to the contralateral mirror abnormality

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