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doi: 10.1007/S40520-020-01616-X 216 FissiSGoriERomoliniA

In-depth research reveals that the activation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling cascade increases the phosphorylation of glycogen synthase kinase 3 (GSK3), boosts the production of glycogen in insulin-stimulated HepG2 cells, reduces blood sugar concentration levels, and improves insulin resistance (Liu and Ji, 2024

Increased GH then triggers the liver to produce IGF-1 (Insulin-like Growth Factor-1), which plays a vital role in muscle growth

van Bladere PJ

All IGF-1treated mice showed an increase in body length compared with untreated mice (Figure 5c)

China J Gen Surg