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Burden and treatment patterns of invasive fungal infections in hospitalized patients in the Middle East: real-world data from Saudi Arabia and Lebanon

404 Importantly, the HPA axis is also modulated by inflammatory cytokines such as IL-1, IL-6, and TNF-

It is also formed naturally in small amounts in the body as an end-product of lipid oxidation and the metabolism of -hydroxyamino acids 18

The most commonly affected area is the terminal ileum (ileitis or regional enteritis), but the disease frequently extends into the colon (ileocolitis)

2 Fe (1) 3+ + ascorbate 2 Fe 2+ + dehydroascorbate 2 Fe (2) 2+ + 2 H 2 O 2 2 Fe 3+ + 2OH + 2 OH Vitamin C is a reducing agent and antioxidant, and reacts with reactive oxygen species, such as the hydroxyl radical

Homocysteine, a risk factor for cardiovascular disease, interferes with the translational reading of SECIS in the expression of GPx1 [53] and, therefore, inhibits the expression of GPx1 promoting the increase of oxygen species reagents that inactivate nitric oxide and cause endothelial dysfunction