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In the past decades, most studies on the mode of cell injury have been limited to necrosis and apoptosis

Existing reactions that may be described as click biology include split intein reconstitution, spontaneous isopeptide bond formation by SpyTag and SpyCatcher and suicide enzyme reaction with small-molecule ligands (HaloTag and SNAP-tag)

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DOI: 10.1038/s41598-017-01078-8 Casarini L & Simoni M (2018) Two Hormones for One Receptor: Evolution, Biochemistry, Actions and Pathophysiology of LH and hCG Endocr Rev 39(5):549592