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In vitro , quercetin can promote oocyte maturation and early embryonic development in humans and aged mice by clearing mitochondrial reactive oxygen species (ROS), reducing apoptosis, and improving autophagy ( Caenorhabditis elegans with heat-stress tolerance by regulating insulin-like signaling and the p38-mitogen-activated protein kinase (MAPK) pathway (Sugawara and Sakamoto, 2020)

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Thus, following MCAO, GPx1 / mice had decreased microvascular perfusion and increased vascular permeability compared to wildtype mice

f , g , Immunostaining of CD68+ cells ( f ) and quantification ( g ) of liver sections

The expression of autophagy genes is increased in HepG2 ATP7B-KO and PHH WD cells To validate the copper-dependent gene regulation in HepG2 and HepG2 ATP7B-KO cells, both were cultured in RPMI medium, contrasting with the GSE107323 dataset, which used DMEM and RPMI medium, respectively